The long-term and high-dose painkillers’ use like diclofenan and ibuprofen is hazardous to cause heart attack in a similar way as is the use of drug Vioxx that was withdrawn because of the potential dangers, as told by the researchers.
Presenting results of one big international study in a painkillers class known as NSAIDs, according to the researchers their high doses increase risk of heart attack, death from the cardiovascular disease and stroke, by about a third.
That means for every thousand people with average heart disease risk who take high dose ibuprofen o diclofenac for one year, around 3 extra would’ve heart attack that is avoidable, from which one could be fatal, as told by researchers.
That puts generic NSAIDs heart risks on par with one clear NSAIDs class, known as coxibs or COX-2 inhibitors, that includes the painkiller Vioxx which Merck, the US drug-maker pulled out from sale during the year 2004 for having links to many heart risks.Some drugs in coxib class also include cerecoxib that’s sold under brand name of Celebrex by Pfizer and also sold under brand name of Arcoxia, by Merck.
Colin Baigent of the Oxford University’s clinical trial unit said that diclofenac, ibuprofen and coxibs have the same risks but also, they have the similar benefits. He stressed on the fact that these risks are majorly relevant to the people suffering from chronic pain, like the patients who have arthritis and are bound to take painkillers’ high doses, such as ibuprofen 2400mg in a day or 150mg diclofenac – for quite long periods.
He said that tablets with lower dose purchased for short course, for instance, for muscle sprain isn’t normally hazardous.
Data was gathered by study team, including hospital admissions for gastrointestinal or cardiovascular disease, from the randomized trials which previously have tested NSAIDs. Having this permitted them to have results of the 639 trials pooled, involving over 300,000 people as well as re-analyze data for establishing NSAIDs risks in some particular patients’ types.
The study also found that naproxen’s high dose, another NSAID, didn’t seem to increase heart attack risks.
According to Baigent, it was quite important that the patients shouldn’t take any quick decisions or have their treatment changed without consulting doctor.
He said that for a lot of arthritis patients, these NSAIDs reduce swelling and joint pain effectively and also help them enjoy life at reasonable quality. He further said that the drugs do have the risks but benefits also so the risks must be presented carefully.
A therapeutics and clinical pharmacology’s professor, Donald Singer, said that powerful drugs might have serious effects, harmful ones, so it is important for the prescribes to ensure that patients are totally informed regarding the medicines that are taken by them.